Products

Erwinase®

ERWINASE®: 10,000 U,
powder for solution for injection.
(INN: Erwinia chrysanthemi L-asparaginase, crisantaspase)

ERWINASE® is indicated for the treatment of Acute Lymphoblastic Leukaemia (ALL).
Asparagine is an amino acid that is essential for cell growth; it is produced by most cells, but not all blood cells. Mutated (cancer) cells in ALL rely on asparagine circulating in the blood for growth. L-asparaginase is an enzyme that lowers circulating asparagine levels in the blood thereby depriving the mutated blood cells of asparagine and inhibiting their growth.

There are different types of L-asparaginase available, each derived from a different bacterium. Patients receiving treatment with L-asparaginase derived from Escherichia coli, who develop hypersensitivity to that form of the enzyme, may be able to continue treatment with ERWINASE® as the enzymes are immunologically distinct. Antibodies targeting E. coli derived L-Asparaginase have been shown not to cross-react with ERWINASE®.

For information on our products, where they are available and prescribing information, please see the Product Summary table.

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